Current studies

Research at East Sussex Healthcare NHS Trust

Current studies at East Sussex Healthcare NHS Trust.

Accordion

Perioperative Quality Improvement Programme (PQIP)

Perioperative Quality Improvement Programme (PQIP)

Summary – The Perioperative Quality Improvement Programme (PQIP) is an exciting and novel project being piloted in the NHS. Our aim is to improve the care and treatment of patients undergoing major surgery in the United Kingdom.

Local Principal Investigator – Dr Sinan Bahlool

WebsitePQIP


SINFONIA logo

SINFONIA trial

Summary – To determine whether sugammadex is superior to neostigmine after elective or emergency major abdominal or non-cardiac thoracic surgery in terms of days alive and out of hospital at 30 days

Principal Investigator – Dr Judith Highgate

WebsiteTrial overview

HPS-4 TIMI 65 ORION-4 - logo

ORION 4

Summary – a clinical trial testing whether a new medicine called inclisiran prevents heart attacks and strokes.

Local Principal Investigator – Dr Katarzyna Dickinson

WebsiteORION 4

SIGNET - logo

SIGNET will be the largest randomised controlled trial in organ donation. The trial will evaluate the benefits of Simvastatin given to organ donors on outcomes in organ recipients.

Summary – Statins in Organ Donor Management An evaluation of the benefits of a single dose of Simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients

WebsiteSIGNET

Local Principal Investigator – Dr Sinan Bahlool

Join demential research - logo

A UK-wide service that makes it easy for anyone to take part in vital dementia research. Anyone over 18 can sign up, whether you have dementia or not.

Simply register your details and a researcher will be in touch when an appropriate study becomes available. You can decide whether to take part in individual studies, with no obligation.

WebsiteJoin Dementia Research


MINDER study

Summary – Minder is an award winning study that aims to improve the lives of people with dementia.

Principal Investigator –  Jo-Anne Taylor

WebsiteMINDER study

BADBIR study

Summary –  The purpose of the research study is to assess whether new biologic or immunomodulator treatments (such as Benepali, Cosentyx, Taltz, Humira, Stelara) used in the treatment of psoriasis have a greater risk of serious side effects or long term health problems than established treatments such as ciclosporin, methotrexate and PUVA.

Principal Investigator – Dr Noor Alwash

WebsiteBADBIR


MyMelanoma

MyMelanoma

Summary – MyMelanoma is recruiting 20,000 melanoma patients to join the largest study of melanoma ever performed. A study designed to answer the most important current questions about melanoma and its treatment.

WebsiteMyMelanoma

The DRAFT3-CASP Study

Summary – This study aims to compare two treatment methods that are currently standard care for treating wrist fractures

Principal Investigator – Dr Kavitha Anoop

Website –  The DRAFT3-CASP Study

Targeting Immune Pathways

Summary – The immune system is a network of cells, tissues and organs that work together to defend the body against infection. Over 70% of the immune system is based in the gastrointestinal tract where it plays a major role in a complex interaction with trillions of microbes to maintain health. The breakdown of this interaction leads to diseases such as inflammatory bowel disease (IBD) and contributes to many others including colorectal cancer.

We work on the nature of intestinal immune responses in health including diseases such as IBD and in the inflammation associated with some gastrointestinal cancers. We have used modern single cell technologies to redefine the cells of the human intestine (3). These technologies allow us to build a map of rare intestinal tissue cells in health and disease. Using this approach, we have discovered novel non-uniformity between various cell types and have then compared how these new cell types change to drive disease. We’ve also defined transcription factors and surface markers that enable these cells to be knocked out for studies in model systems and defined key cellular changes demonstrating new avenues for therapeutic targeting in this disease.

Around 40% of patients fail to respond or adequately respond to available immunotherapies. In this work, we will build on our previous findings to explore how the immune system is imbalanced in chronic inflammation associated colorectal cancer. This study will create an atlas of rare human intestinal cells and will highlight pathways that drive inflammation in early disease compared to chronic unresponsive disease. Based on this information we will generate disease identifiers capable of indicating inflammation or responsiveness to particular therapies. In addition, we will generate novel drug targets for those with unresponsive IBD and colorectal cancer.

Local Principal Investigator – Judith Tidbury

OBS UK Study

Summary – Heavy bleeding during and after birth is the most common problem when giving birth to a baby. We have created a new way of managing heavy bleeding during and after childbirth (called the OBS UK care bundle). This care bundle helps to recognise bleeding early and to standardise the treatment of heavy bleeding during childbirth. When this package of care was introduced in Wales, we found that the number of women and birthing people who needed a blood transfusion was reduced and that fewer had very large bleeds. We now need to run this larger study to see whether the improvements seen in Wales can be seen across the wider NHS. If the OBS UK care bundle is shown to make a big improvement to outcomes, then it may advise the new UK standard guidance for dealing with heavy bleeding during and after childbirth.

Principal Investigator – Dr Seema Pai

WebsiteOBSUK Study

MND Register for England, Wales and Northern Ireland

Summary – Every single person with motor neurone disease (MND) can help the global effort to find causes, treatments and ultimately a cure for MND. By allowing us to collect your data your details will become part of the big picture, helping researchers focus their knowledge and expertise in the right areas.

Principal Investigator – Simon Wilson

Website –  MND Register | MND Association


MS Register logo

MS Register

Summary – How many people in the UK are living with MS? How do the different types of MS affect different people? Are there regional differences in how people with MS receive treatment?

Currently, the answers to these fundamental questions are largely unknown. With an estimated 100,000 people living with MS in the UK, more data needs to be gathered about the physical, environmental and social effects for people and carers affected by the condition.

Principal Investigator – Janet Sinclair

WebsiteMS Register


NHS Cancer Vaccine Launchpad (NHS CVLP)

Summary – The NHS Cancer Vaccine Launch Pad (CVLP) is a platform that will speed up access to messenger ribonucleic acid (mRNA) personalised cancer vaccine clinical trials for people who have been diagnosed with cancer. It will also accelerate the development of cancer vaccines as a form of cancer treatment.

Principal Investigator – Dr Aspasia Soultati

WebsiteNHS Cancer Vaccine Launch Pad


Study Title – The impact of psychological stress on cancer burden and recurrence in ovarian cancer

Summary – The treatment of advanced ovarian cancer uses therapies to extend the amount of time before requiring more treatment. In the first instance, this is through a combination of chemotherapy and surgery. There is evidence to suggest that stress may have a part to play in weakening the immune system and changing the behaviour of the disease. We would like to explore this further by following the stress levels of women during treatment and follow up for ovarian cancer.

Local Principal Investigator – Dr Kate Lankester

WebsiteUniversity of Brighton


UK Adult ITP Registry

Summary – Aim is to collect clinical information (age at onset, bleeding symptoms, treatments given and responses), standard lab tests, and investigational assays. All this information will be analysed looking for associations between the presence of genetic variations and (i) development of ITP, (ii) responses to treatment, (iii) severity of ITP and several other parameters.

Principal Investigator – Dr Anna Cowley

WebsiteUK Adult ITP Registry

DUALITY

Summary – Dual mobility versus standard articulation total hip replacement in the treatment of older adults with a hip fracture.

Local Principal Investigator – Mr Christopher Buckle


Part logo

The PART Trial

Summary –  The clinical and cost-effectiveness of elective primary total knee replacement with PAtellar Resurfacing compared to selective patellar resurfacing. A pragmatic multicentre randomised controlled Trial with blinding (PART)

Principal Investigator – Mr Christopher Buckle

Website – PART – Bristol Trials Centre

BASE logo

Study Title – BASE trial

Summary – looking at the use of sodium bicarbonate for metabolic acidosis in very preterm babies

Principal Investigator – Dr Mani Kandasamy

WebsiteBASE | NPEU


SPIROMAC logo

SPIROmetry to Manage Asthma in Children

Summary – The SPIROMAC study will see if a breathing test called spirometry every three months can help prevent asthma attacks.

Principal Investigator – Dr Oana Anton

Website – SPIROMAC

GenOMICC - logo

Genetics of susceptibility and mortality in critical care (GenOMICC)

Summary – Infectious diseases and severe injuries affect millions of people around the world every year. Most cases are mild, but some people become very unwell. Our genes (or DNA) determine how vulnerable we are to critical illness. If we could find the genes that cause some people to be more vulnerable, we may be able to develop better treatments for patients in the future.

Local Principal Investigator – Dr Judith Highgate

WebsiteGenOMICC

ASPECT logo

ASPECT trial

Summary – The ASPECT Study is a Randomised Controlled Trial, or RCT. It is investigating whether aspirin reduces the risk of a heart attack or stroke in patients who are admitted to hospital with pneumonia.

Principal Investigator – Dr Thereza Christopherson

WebsiteASPECT Study – Aspirin after hospitalisation with Pneumonia to prevent cardiovascular Events randomised Controlled Trial

PhEAST study

Summary – To assess whether Pharyngeal Electrical Stimulation (PES) is safe and effective at improving post-stroke dysphagia (PSD).

Principal Investigator – Sarah Underwood

WebsitePhEAST


TICH-3 trial

Summary – To assess the clinical effectiveness of TXA after ICH and determine whether TXA should be used in clinical practice.

Principal Investigator – Dr Chemindra Biyanwila

WebsiteTICH-3

Extend - logo

The EXTEND trial

Summary – EXTENDed antibiotics to improve outcomes in patients with complicated intra-abdominal infection.

Local Principal Investigator – Mr Yesar El-Dhuwaib

WebsiteThe EXTEND trial

The Partial Trial

Summary – PARTIAL is a research study looking at two different types of surgery for kidney cancer.

Principal Investigator – Mr Karl Spiteri

WebsitePartial